6 Best Probiotics for Men


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Dr. Jennifer Hughes, MD
Medical Reviewer

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Most people interested in health and wellness are aware of probiotics—but it’s lesser known that probiotic supplements can be specifically targeted to the different sexes.  

Probiotics are characteristically linked to gut health and digestion, but probiotics can also support immunity and mood, as well as men’s health like testosterone levels, reproduction, and fertility. 

Keep reading to learn more about the top probiotics for men recommended by our team, taking into account their price, ingredient formulation, and the number and quality of bacterial strains.

Ancient Nutrition SBO Probiotics Men’s
  • Description

    The top recommended probiotic for men is this high-potency formula containing not only 25 billion CFUs of live probiotics but also superfood ingredients for men’s health and medicinal mushrooms.

Top 6 Best Probiotics for Men

ProbioticBenefitsCFU & StrainsCost
Ancient Nutrition SBO Probiotics Men’s Male reproductive and hormone health; Functional mushrooms provide adaptogenic support25 billion CFUs from 4 strains; Selenium and zinc; Organic fermented botanical blend; Organic mushroom blend$49.95 for 30 servings
Garden of Life Dr. Formulated Probiotics Once Daily Men’sColon and general digestive health; Reduces gas Immune health50 billion CFUs from 15 strains; Prebiotic fiber blend$42.99 for 30 servings
Solaray Mycrobiome Probiotic – Men’s FormulaMale reproductive health; Digestion and immunity30 billion CFUs from 24 strains; Prebiotic fiber$38.59 for 30 servings 
Nordic Naturals Nordic Flora Probiotic DailyGeneral health and wellness; Digestion and immunity12 billion CFUs from 4 strains; Prebiotic fiber$29.95 for 30 servings
Ancient Nutrition SBO Probiotics Gut RestoreStrong formulation to support gut health; Reduces gas, bloating, and IBS symptoms; Functional mushrooms provide adaptogenic support25 billion CFUs from 4 strains; Magnesium and zinc; Fermented botanical blend; Organic mushroom blend$49.95 for 30 servings
NOW Probiotic-10™ 25 BillionDigestive system support; Immune system support25 billion CFUs from 10 strains $49.99 for 100 servings 

Now, let’s jump into the details about the top six probiotics for men.

Best Overall: Ancient Nutrition SBO Probiotics Men’s

ancient nutrition sbo probiotics men's
  • Pros
  • Specifically targeted for men’s health
  • Uses soil-based probiotics, prebiotics, and postbiotics
  • Contains additional ingredients like organic mushrooms and fermented botanicals
  • Cons
  • More expensive
  • Requires two daily capsules

Best for: Men wanting to improve hormone health and vitality in addition to gut function.

The Ancient Nutrition SBO Probiotic Men’s has ingredients specifically targeted for men’s health. 

In addition to 25 billion CFUs of clinically studied probiotics, this supplement contains superfoods like organic fermented ginger root, fenugreek seed, and fo-ti root, which have all been used for centuries to support male health. 

Specifically, fo-ti root is known as the “Elixir of Life” in some Asian cultures and may promote sexual vigor and fertility in males, and fenugreek seed is linked to increased testosterone levels.

This Ancient Nutrition supplement contains beneficial superfood compounds, including organic licorice, marshmallow, zinc, magnesium, and the functional mushrooms maitake, turkey tail, reishi, and shitake. 

Best for General Gut Health: Garden of Life Once Daily Men’s

garden of life dr formulated once daily men's probiotic
  • Pros
  • High amount of CFUs and strains
  • Doctor-formulated by a gut health expert
  • Doesn’t require refrigeration
  • Cons
  • On the expensive side

Best for: Men needing support for immune and digestive health, including reducing gas.

Garden of Life Dr. Formulated Probiotics Once Daily Men’s is a probiotic supplement formulated for men’s health. 

Containing a high quantity of both CFUs (colony-forming units) and bacterial strains, this probiotic from the well-known brand Garden of Life is a potent option for men with digestive or immune concerns. 

Two of the prominent bacteria in this supplement are Lactobacilli and Bifidobacteria, which are well-known genera for supporting colon health and digestive function as a whole.

Plus, the formula contains beneficial whole-food prebiotics—a group of fibrous carbohydrates that healthy bacteria consume to grow and thrive in the gut. 

Best for Prostate Health: Solaray Men’s Formula

solaray probiotic men's formula
  • Pros
  • Contains prebiotics and probiotics
  • High number of bacterial strains
  • Specifically targeted for male reproductive health
  • Cons
  • Requires refrigeration

Best for: Those wanting targeted support for male reproductive concerns, including fertility, prostate function, and testosterone levels. 

With an impressive 30 billion CFUs from 24 bacterial strains, the Solaray Mycrobiome Probiotic Men’s Formula is a combination of prebiotics and probiotics that can benefit men’s digestive health. 

Fourteen of the 24 bacterial strains are specifically formatted for men’s health, including Lactobacillus acidophilus and Lactobacillus casei, which have been studied for their role in supporting testosterone levels, prostate health, and male fertility. 

Solaray’s Mycrobiome Men’s Formula also utilizes an enteric-coated capsule, which is designed to enable the beneficial bacteria to travel through the harsh acidic environment of the stomach and make it to the lower intestines unscathed. 

While this probiotic supplement does require refrigeration upon receiving it, it can survive unrefrigerated shipping, as the bacteria will be stable for up to seven days in extreme heat conditions.

Best for General Health: Nordic Naturals Nordic Flora Probiotic Daily

nordic flora probiotic daily
  • Pros
  • Affordable option
  • Good for general health
  • Cons
  • Fewer CFUs and bacterial strains than other brands
  • Not specifically targeted for men’s health

Best for: Men seeking general support for health and wellness.

Nordic Naturals is a well-trusted brand for providing top-rated omega-3 and fish oil supplements, but it also carries high-quality probiotics, like the Nordic Naturals Nordic Flora Probiotic Daily

Although it has a slightly lower bacterial count at 12 billion CFUs, this probiotic is suitable for men wanting general wellness support. 

While it only contains four bacterial strains, this group is among the most studied bacterial species, including Lactobacillus acidophilus DDS-1, the first commercially available probiotic for dietary supplements. 

In addition to L. acidophilus, the other species include Bifidobacterium longum and Bifidobacterium bifidum, which support digestive function and may reduce the risk of colon cancer.

Best for Chronic Digestive Issues: Ancient Nutrition Gut Restore

Ancient Nutrition SBO Probiotics Gut Restore
  • Pros
  • Targeted for gut health
  • Uses soil-based probiotics, prebiotics, and postbiotics
  • Contains additional ingredients like organic mushrooms and fermented botanicals
  • Cons
  • Higher price point
  • Requires two daily capsules

Best for: Men with gas, bloating, diarrhea, or irritable bowel syndrome (IBS).

One of the leading benefits of the Ancient Nutrition SBO Probiotics Gut Restore is the “SBO” part of its name.

Standing for soil-based organisms, SBO probiotics are microbes that naturally occur in soil—they are resilient, shelf-stable, and designed to thrive in the high temperatures of the gut.

The Ancient Nutrition Gut Restore probiotic uses a trifecta approach to heal the gut, with prebiotics, probiotics, and postbiotics—beneficial metabolites (like enzymes and organic acids) that are created when probiotics consume prebiotic fibers.

Two unique ingredients in this probiotic are the organic fermented licorice root and marshmallow root, which are soothing botanicals that can restore gut integrity and reduce inflammation.  

This probiotic is best for men with digestive concerns because it contains 25 billion CFUs from four microbial strains (three are bacteria and one is a yeast), which are a proprietary and clinically studied blend that may reduce constipation, gas, and bloating while supporting healthy bowel transit and digestion.

Best Budget Pick: NOW Probiotic-10™ 25 Billion

now probiotic-10 25 billion
  • Pros
  • Highly affordable
  • Clinically validated bacterial strains
  • Cons
  • Requires refrigeration after opening
  • Not specifically targeted for men’s health

Best for: Men on a budget wanting general digestive support. 

The NOW Probiotic-10™ 25 Billion contains a potent mixture of 25 billion CFUs from ten acid-resistant probiotic bacterial strains that have been found to colonize in the intestines—and with 100 servings per bottle, this is by far the most affordable on the list. 

The ten bacterial strains in this probiotic have been clinically studied for their role in maintaining gut integrity, supporting intestinal motility, and helping to facilitate the detoxification process. 

One of the beneficial bacterial species found in this probiotic is Lactobacillus rhamnosus, which is acid-resistant and has shown great ability to adhere to the intestinal tract. 

Uniquely, NOW Foods uses a DNA-fingerprinting technology to help verify the identity and purity of its probiotic strains.

What Are Probiotics? 

Housing upwards of 100 trillion bacteria, the human intestines contain a wide diversity of microbes—which can be good, bad, or neutral.

Although gut bacteria were once thought to only play a role in digesting food and synthesizing certain vitamins, research over the past two decades has exploded with new insights into how these microbes affect human health. 

One way to support the diversity and strength of our gut microbiomes is with supplemental probiotics, which contain healthy bacteria that benefit not only our gut health but also immunity, energy, mood, skin, and more. 

Probiotics for Men’s Health

Certain probiotic strains can target aspects of men’s health, including hormone levels, reproduction, fertility, and prostate function.  

Some bacterial species that benefit men’s health include Lactobacillus acidophilus and Lactobacillus casei, which may improve testosterone levels, prostate health, and fertility. 

The species Lactobacillus rhamnosus and Bifidobacterium longum have also been studied for their role in enhancing sperm quality, which could lead to improved male reproduction and fertility. 

The probiotic Lactobacillus reuteri has also been shown to boost testosterone levels in animal studies, but human research has not verified this yet. 

FAQs About Probiotics for Men

Do Probiotics Do Anything for Men?

Yes, probiotics can benefit men, as certain bacterial strains have been found to improve male-specific health concerns like prostate function, fertility, reproduction, and testosterone levels. 

Probiotics can also benefit men by improving digestion and immune function. 

What Is the #1 Probiotic?

The top probiotic for men recommended by our team is the Ancient Nutrition SBO Probiotics Men’s because it contains not only 25 billion CFUs of live probiotics but also superfood ingredients for men’s health and medicinal mushrooms.

What Are the Signs You Need Probiotics?

You may need probiotics if you have any digestive problems, including excess gas, diarrhea, constipation, bloating, or irritable bowel syndrome (IBS). 

There are also many non-digestive signs that you need probiotics, including poor immunity or getting sick constantly, mood disorders, and acne or other skin issues. 

How Often Should Men Take Probiotics?

It’s recommended to take probiotics daily, as they tend to work better when consumed on a consistent basis. 

Is It Better to Take Probiotics in the Morning or at Night?

The best time to take a probiotic is on an empty stomach, which could be either first thing in the morning before eating or just before going to sleep at night—as long as you hadn’t eaten dinner just prior. 

Probiotics tend to be the most effective when taken on an empty stomach because your stomach acid levels are naturally lower and will allow the bacteria to travel to the large intestine safely.

Do Probiotics Increase Testosterone?

Some probiotic strains can increase testosterone levels. 

The most-studied bacterial strains that are linked to increased testosterone levels are Lactobacillus acidophilus, Lactobacillus reuteri, and Lactobacillus casei

The probiotic supplement Ancient Nutrition SBO Probiotics Men’s also may increase testosterone, as it contains the botanical ingredients fo-ti root and fenugreek seed, which are linked to increased testosterone levels and fertility. 

Key Takeaways

  • Probiotic supplements can benefit most people, but there are several male-specific probiotics that can target specific health concerns.
  • Probiotics for men can not only improve digestion and immunity but also help to boost testosterone levels and support male fertility, prostate health, and reproductive function.

Çiftci G, Tuna E. Effects of cholesterol and Lactobacillus acidophilus on testicular function. Clin Exp Reprod Med. 2021;48(3):229-235. doi:10.5653/cerm.2020.04322

Poutahidis T, Springer A, Levkovich T, et al. Probiotic microbes sustain youthful serum testosterone levels and testicular size in aging mice. PLoS One. 2014;9(1):e84877. Published 2014 Jan 2. doi:10.1371/journal.pone.0084877

Singh J, Rivenson A, Tomita M, Shimamura S, Ishibashi N, Reddy BS. Bifidobacterium longum, a lactic acid-producing intestinal bacterium inhibits colon cancer and modulates the intermediate biomarkers of colon carcinogenesis. Carcinogenesis. 1997;18(4):833-841. doi:10.1093/carcin/18.4.833

Valcarce DG, Genovés S, Riesco MF, et al. Probiotic administration improves sperm quality in asthenozoospermic human donors. Benef Microbes. 2017;8(2):193-206. doi:10.3920/BM2016.0122

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