Top 5 Picks for the Best NMN Supplement in 2024

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Editor’s Note: NMN supplements are not intended to diagnose, treat, cure, or prevent any disease. Before adding any supplements to your diet, it’s important to talk with your doctor about your unique situation and any potential risks and benefits you should consider. In early 2023, the Food and Drug Administration (FDA) decided to investigate a form of NMN (beta-NMN) as a pharmaceutical drug instead of a dietary supplement because of its success in clinical trials, leading suppliers like Amazon to take NMN supplements off their shelves. As of October 2023, this ruling is still active, but may change at any time. You can still find NMN supplements on many retailers’ websites. 

Recent years have seen an increased demand for NMN supplements (nicotinamide mononucleotide), a direct precursor to the vital molecule NAD+ (nicotinamide adenine dinucleotide) that has been linked to anti-aging and longevity. 

However, the rise in popularity of NMN supplements has seen a subsequent increase in not-so-great brands flooding the market with adulterated or untested versions of this NAD+ precursor.

Not to worry—we’ve got you covered with the five best NMN supplements on the market today, whether you want pure NMN supplements or a combination of anti-aging and health-supporting compounds.

TNI Main Logo 700x432 1 Best Overall
Wonderfeel® Youngr™ NMN
for Metabolic Health
Lifeforce Peak NMN
Most Affordable
PartiQlar Pure NMN Capsules
Best NMN Supplement Wonderfeel® Youngr Lifeforce PartiQlar
NMN Dosage and Form 900mg capsules 375mg capsules 500mg capsules
Cost $88 for 30 servings
($2.93/serving)
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$90 for 30 servings
($3.00/serving)
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$71.99 for 60 servings
($1.20/serving)
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Best for: Anyone looking for a high-quality NMN supplement with supportive ingredients for longevity and overall health. 

Wonderfeel® Youngr™ NMN is our top pick for the best NMN supplement, as it contains higher doses of NMN than many other brands, offers several other health-supporting ingredients, and is developed and backed by Dr. Andrew Salzman, a Harvard doctor and biomedical researcher. 

In each two-capsule serving of Wonderfeel® Youngr™ NMN, you’ll find:

  • 900mg of nicotinamide mononucleotide (NMN)
  • 20mcg of vitamin D (100% of the daily value)
  • 100mg of trans-resveratrol (the most biologically active form of resveratrol that is linked to cognitive, cardiovascular, and cellular health) 
  • 50mg of olive leaf extract, which contains the antioxidant hydroxytyrosol that supports cardiovascular health and fights inflammation
  • 4mg of ergothioneine, a potent antioxidant that fights oxidative stress and is linked to reduced mortality  

NMN and resveratrol are a well-known anti-aging duo, as studies show that combining the two boosts NAD+ levels more than either one taken alone. 

While this supplement is pricey, at $88 for a one-month supply, you can shave off $15 by using the subscription plan, reducing it to $73 per month. 

Plus, the abundance of supportive compounds found here—some of which, on their own, can cost similar amounts—makes Wonderfeel® Youngr™ NMN a worthwhile supplement if you’re interested in anti-aging.

Best for: People looking for a moderate-dose NMN supplement that supports metabolic health. 

Co-founded by famed motivational speaker Tony Robbins, Lifeforce is a recent leader in the precision medicine space, along with their high-quality nutraceutical supplements—like Lifeforce Peak NMN, which is one of the best NMN supplements for metabolic health.

Lifeforce Peak NMN contains a moderate NMN dose (375mg) alongside supportive ingredients for metabolic health, weight loss, and blood sugar control, like berberine and white mulberry extract.

It also includes lithium orotate and spermidine—an antioxidant compound that boosts cellular autophagy (our internal housekeeping system that removes toxic or dysfunctional cells) and may support cognition.

While lithium is best known for its role in treating bipolar disorder, low-dose lithium orotate has recently been studied as a nootropic that may promote healthy neurotransmitter activity and potentially support cardiovascular and metabolic health. 

Although this is an expensive supplement ($3/dose without a subscription), there is a range of recommended serving sizes of one to three capsules. If you take just one capsule per day, this would become one of the more affordable NMN supplements at $1/dose (but that would also decrease the amount of NMN to only 125mg per day). 

Plus, while their website states that “Peak NMN™ includes only HPLC-tested NMN with 99% purity and 24 months’ stability,” they don’t provide a Certificate of Analysis on their website showing said NMN purity or potency.

Best for: People who want pure NMN capsules with no additional compounds at a reasonable price. 

PartiQlar Pure NMN Capsules are the most affordable NMN supplements—but they don’t skimp on quality or potency. 

They provide a moderate NMN dose—500mg of NMN per capsule—and a two-month supply in each bottle. 

We love that this NMN supplement prominently displays its Certificate of Analysis, showing third-party testing results for the NMN purity of 99%. 

PartiQlar sources their NMN from Effepharm—the world’s leading NMN supplier with 99% purity, USP compliance,NSF certification, GMP compliance (Good Manufacturing Practices). 

While you won’t find any additional supportive ingredients in this supplement, many people don’t want the extra stuff—they just want a pure NMN supplement, and PartiQlar Pure NMN Capsules are a great option.

Best for: People looking for a powdered supplement that combines NMN with other anti-aging compounds. 

ProHealth Longevity NMN Pro Complete perfectly balances three longevity-supporting ingredients: NMN, trans-resveratrol, and TMG. 

While we’ve already mentioned the health benefits of taking NMN and trans-resveratrol together, TMG is a lesser-known compound—it’s an amino acid (also known as betaine anhydrous) that acts as a methyl donor, helping to replenish the body’s methyl pool.

As NMN supplementation can require using methyl groups to facilitate the conversion into NAD+, methyl depletion can occur—especially in people with common gene mutations or increasing age. 

Therefore, adding TMG to your NMN supplement can help to protect your methyl pool, which is necessary for actions like detoxification and the production of antioxidants, hormones, and neurotransmitters. 

We also love that ProHealth Longevity NMN Pro Complete undergoes third-party testing for each batch, with the COA results displayed and easily accessible. 

This powder also mixes easily into food and water—but if you don’t want to deal with powder, they also offer a capsule form of this supplement

However, this NMN supplement is pricey, and you only get 15 servings per container (although you can purchase a larger size if desired). 

Best for: People looking for an affordable sublingual NMN powder to support absorption. 

Renue By Science NMN Powder is a great choice for sublingual NMN—meaning it dissolves under the tongue. 

Rather than taking capsules or powders added to food or drinks, sublingual powders get placed directly under the tongue and partially bypass digestion in the stomach and intestines, allowing for increased bioavailability. 

This NMN supplement is a pure NMN powder with a moderate dose of 500mg per serving—and you’ll find an impressive 200 servings per container. 

Sublingual NMN is also fast-acting, which may lead to a more significant boost in energy production than other forms of NMN. 

However, this supplement is a pure NMN powder (no supportive compounds), and there are no published reviews on the site, so we can’t comment on the taste of the powder.

What Do NMN Supplements Do in the Body?

NMN (nicotinamide mononucleotide) is a naturally occurring molecule found in small amounts in foods like broccoli, cabbage, and avocado. 

However, its biggest claim to fame is its status as a precursor to another molecule known as NAD+ (nicotinamide adenine dinucleotide).

NAD+ is a vital coenzyme—meaning, it’s a “helper” molecule that assists other enzymes to do their jobs properly—and is found in virtually every cell in the human body.

It’s involved with processes ranging from brain cell growth to DNA repair to helping with mitochondrial energy production. 

Without enough NAD+, our cells, organs, and tissues can’t function properly—and without any NAD+ in our body, we’d die almost instantly. 

Despite its essentiality, NAD+ levels decline with age, leading to accelerated aging and age-associated physiological decline, like the development of age-related diseases. 

Some research has found that NAD+ can drop by as much as 50% between the ages of 40 and 60, with an additional decline upon reaching older age. 

With NAD+ depletion, every organ system starts to run at suboptimal levels, leading to metabolic disorders like diabetes, hypertension, heart disease, cognitive decline, liver and kidney conditions, muscle loss, and more. 

Other than directly boosting levels of NAD+, NMN has also been studied for its effects on improving health markers associated with age-associated physiological decline.

While much of the research has only been conducted in animals or with cell-based cultures, several human clinical trials on NMN supplements have been recently published or are currently in the works. 

Some of the leading potential health benefits of NMN supplements include:

  • Healthy aging. Research has found that boosting NAD+ (nicotinamide adenine dinucleotide) levels through NAD+ precursors like NMN can extend the lifespan of species like yeast and worms. However, the research on NMN and lifespan in mammals is still lacking—we will need many additional studies before we can state if NMN supplements can lengthen lifespan in humans. 
  • Metabolic health. NMN supplementation has shown promise for improving insulin sensitivity in the skeletal muscle of prediabetic women and mice
  • Reduced body weight. In research with mice, supplementing with either 100 or 300 mg/kg of body weight of NMN for 12 months reduced body weight by 4% and 9%, respectively. 
  • Brain health. Studies with mice show that NMN supplementation inhibits beta-amyloid plaque buildup, improves working memory, and repairs the neurovascular system—how the brain receives oxygen and critical nutrients through blood vessels. 

Muscle health and exercise performance. We have the most human-based research in this area. Human clinical trials have shown that NMN supplements boost aerobic capacity in healthy adults and improve muscle strength, gait speed, and left-hand grip test strength in older Japanese men.

NMN Supplement FAQs

What Are the Best NMN Supplements?

There are many reputable brands of NMN supplements—some of our favorite NMN brands that verify their purity and potency with third-party testing include:
Wonderfeel® Youngr™ NMN 
PartiQlar Pure NMN Capsules
ProHealth Longevity NMN Pro Complete 
Renue By Science NMN Powder

How Much NMN Should I Take?

While there is not enough human research to be definitive here, studies have shown that taking an NMN dose up to 1200mg per day for six weeks and 900mg daily for eight weeks is safe. This isn’t necessarily saying that higher doses aren’t safe—just that they have not been tested. Most supplements on the market have an NMN dose of 250-750mg, with some going up to 1,000mg.

Which Brand of NMN Does David Sinclair Take?

David Sinclair is a prominent longevity researcher who is well-known for taking NMN. While he does not endorse specific brands, he has stated that he takes 1 gram of NMN every morning (in powdered form) mixed with yogurt. He also combines NMN with resveratrol.

What Is the Best Form of NMN for Absorption?

Sublingual NMN and liposomal NMN supplements likely have the best absorption rates, as they bypass normal digestion in the gastrointestinal tract.

Are NMN Supplements Dangerous?

As of now, research has not found any adverse side effects of taking NMN in moderate doses. However, long-term studies on NMN in humans have yet to be conducted.

Is It Better to Take NMN Supplements With Resveratrol?

NMN and resveratrol are a well-known anti-aging duo, as studies show that combining the two boosts NAD+ levels more than either one taken alone. Therefore, many people combine NMN with resveratrol, which can better increase NAD+ stores and support health and longevity. Keep in mind that you need to use “trans-resveratrol,” as that is the only biologically active form of resveratrol.

Does NMN Really Reverse Aging?

NMN does not necessarily “reverse” aging but may improve longevity markers and support healthy aging. Some studies in worms and yeast have shown that NMN extends lifespan. For example, one 2013 study published in Cell found that both NMN and another NAD+ precursor, nicotinamide riboside (NR), extended the lifespan of the commonly studied lab worm, C. elegans, by over 10%. However, the research on NMN and lifespan in rodents and humans is still lacking. We will need additional studies before we can definitively state if NMN can lengthen human lifespan. 

Are NMN Supplements Banned?

You cannot currently buy NMN supplements on Amazon, but most independent retailers are still selling NMN on their websites. The Food and Drug Administration (FDA) recently decided to investigate a form of NMN (beta-NMN) as a pharmaceutical drug instead of a dietary supplement because of its success in clinical trials. A similar turn of events was seen with the compound NAC in 2022, in which Amazon took the supplement off their virtual shelves—but the ruling was reversed, and you can now buy NAC anywhere again. Therefore, most NMN suppliers are confident that the same actions will occur with NMN in the near future.



2 Comments

  • Avatar for Lisa Lisa says:

    I’d like to order and try the NMN 1000mg supplement. Could someone please email me with details on how and where to order in Canada as we lost the GNC store we had here, and other nutritional supplements store due to corrupt city officials.

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