Qualia Senolytic Review: Can It Really Combat Cellular Aging?

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Medically reviewed by:
Dr. Jennifer Hughes, MD

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Using largely plant-based ingredients to scrub your tissues of potentially harmful "zombie cells," Qualia Senolytic from Neurohacker earns an A- from us for top-tier ingredient quality, research support, and more.

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Our Rating:


» Rating Methodology


Our Rating Methodology

We determined this rating by evaluating the following factors:

  • Ingredient Quality: A-
  • Supporting Research: A
  • Reported Side Effects: A
  • Brand Experience: A-
  • Value for the Price: A-
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Believe it or not, many of your body’s cells will be entering “retirement age” before you’ve even finished college, but Neurohacker is putting an asterisk on this inevitable rite of cellular aging with Qualia Senolytic.

This cellular retirement is referred to as senescence, a process in which aging cells stop functioning properly and accumulate in our tissues, which can promote inflammation throughout the body, negatively impact tissue regeneration, and much more.

Using a blend of research-backed compounds covered below, Qualia Senolytic seeks to accurately target and destroy these senescent cells, effectively making room for healthier cells to proliferate through our bodies’ tissues.

We found that Qualia Senolytic delivered on these claims with a safe and scientifically sound formulation, earning an overall rating of A- from our review team

In order to provide a fair and comprehensive assessment of Qualia Senolytic, our review team used our experiences with the product, conversations with the Neurohacker team and plenty of independent research.

As always, we’ll start the breakdown with the pros and cons and a closer look at ingredient quality.

Qualia Senolytic
  • Description

    Qualia Senolytic uses a balanced synergy of plant-derived compounds like fisetin, curcumin, and more to selectively kill aging, senescent cells in our tissues.

  • Ingredients

    Fisetin, Quercefit ® Quercetin Phytosome, Longvida Optimized Curcumin ® Extract, Olive Leaf Extract, Soybean Seed Extract, Luteolin, Milk Thistle Seed Extract, Piperlongumine, Senactive ®

Qualia Senolytic Review: Pros and Cons

  • Pros
  • Research-supported formulation
  • Strong safety profile
  • Smaller capsules
  • Only needs to be taken twice a month
  • Seems effective for cognition and energy (our experience)
  • Cons
  • Six-capsule servings
  • Some adverse effects reported at high concentrations (quercetin)
  • Need more human trial data and dosage guidelines

Ingredient Quality


Grade: A-

Neurohacker discloses most of their Qualia Senolytic ingredient sourcing and manufacturing processes, and the majority of the ingredients themselves are derived from plant sources with no harmful additives thrown in the mix.

Beyond the quality of the ingredients themselves, we award brands credit under this factor for both the caliber of their sourcing/manufacturing practices as well as how accessible they make this information to the public.

Neurohacker provides an exceptionally detailed breakdown of each of the five major ingredients in Qualia Senolytic—fisetin, quercetin phytosome, piperlongumine, Senactive®, and Longvida Optimized Curcumin®—on the Qualia Senolytic product page, including not just their sourcing methodology for each, but general information (e.g., what is fisetin?), “dosing principles and rationale,” “key mechanisms,” and more.

Though Neurohacker doesn’t explicitly detail the country of origin for all of these ingredients, they do explain which plants the ingredients come from as well as the way in which the ingredients are extracted/manufactured from said plants (concentration, other ingredients involved, etc.).

All of the active ingredients are derived from plant sources, and the “other ingredients” include hypromellose, rice extract, rice hulls, gum arabic, and sunflower oil. 

We normally rail against sunflower, seed, and other processed oils in food products for their (potentially) high omega-6 content and pro-inflammatory properties, but this quantity—and the fact that you won’t be cooking and oxidizing the oil—is much less concerning. 

Overall, the quality of the formulation, the lack of harmful additives, and the well-above-average effort Neurohacker puts into educating their customers on every major ingredient has earned the brand an A- for ingredient quality.

Supporting Research


Grade: A

Neurohacker backs up every ingredient in Qualia Senolytic with a wealth of research findings (200+ studies), but we would still like to see more human trial data and more consistent dosage numbers.

Between all of the Qualia Senolytic ingredient profile pages provided on the Neurohacker website, they reference more than 200 studies affirming the effectiveness and safety of the five featured ingredients.

Here are the highlights in terms of research-supported claims of effectiveness as broken down by ingredient.


This Scripps Research Institute study on the “senotherapeutic” potential of 10 plant-based compounds found that fisetin, one such (flavonoid) compound found in many plants, was the most effective in improving “senescence markers, age-related histopathology, disease markers, health span and lifespan” in mice.

Like many studies centered on potentially senolytic agents, researchers are often interested in the tumor suppression potential, but also admit that “aging and age-related diseases” are caused by cellular senescence as well


Like fisetin, quercetin is a flavonoid found abundantly in several varieties of fruits and vegetables, but the quercetin phytosome used in Qualia Senolytic (Quercefit®) is a unique and highly absorbable blend developed by plant-based nutraceutical company Indena

Indena uses sunflower lecithin to dramatically enhance the otherwise poor absorption potential of this natural compound so that the body can use it much more efficiently.

As for the research, this Mayo Clinic article describes how quercetin was “more effective [than the leukemia drug disatinib] against senescent human endothelial cells,” endothelial cells being those that line the blood vessels.


A small molecule native to the long pepper plant, piperlongumine was shown by this University of Arkansas study to safely and selectively kill cells “under high oxidative stress,” which is very often the case with senescent cells.

These researchers and others are still exploring these mechanisms and tinkering with new structural analogues of piperlongumine to enhance effectiveness and broaden the applications, but piperlongumine is firmly a part of the senolytic compound conversation already.


Finally, curcumin, the active compound in turmeric, was shown by this Soochow University (Suzhou, China) study to exert some fairly dramatic effects on “endothelial progenitor cells” (cells that help the inner lining of blood vessels to regenerate).

In diabetic mice experiencing a lack of blood flow to their hind limbs, curcumin application not only helped to clear out senescent endothelial progenitor cells, but actually improved the ability of these cells to build new blood vessels, resulting in significantly improved circulation. 

Overall, we anticipate the relative dearth of human trial data to continually improve, given the acceleration senolytics research has seen over the past five years, but Neurohacker has made a strong case for the objectively measurable, senolytic benefits of its Qualia Senolytic formulation, earning an A for research support.

Evidence for Benefits

We’ve rated the amount of evidence there is for each purported benefit of Qualia Senolytic:

  • Cellular Anti-AgingStrong Evidence
  • Tissue RejuvenationModerate Evidence
  • Healthy Physical FunctionModerate Evidence

Reported Side Effects


Grade: A

Every ingredient in Qualia Senolytic has been confirmed safe by an overwhelming majority of studies reporting very few or zero adverse effects under normal or, in some cases, even ultra-high-dose scenarios.

It’s important to avoid complacency when dealing with plant-based ingredients because the manufacturing processes, resulting concentration changes, and/or the way in which these compounds are removed from their natural environments and synergized with new compounds all leave room for potentially harmful effects.


The strong safety profile of fisetin—which is reportedly safe to consume even at very high doses—is almost unanimously agreed upon by senolysis experts, with the vast majority of studies reporting zero adverse effects associated with the compound.


Quercetin has been similarly appraised in the vein of safety, though very high doses can cause kidney damage and protein dysfunction.

Though it was conducted by Indena themselves, there is a study showing safety data on the more digestible form of quercetin used in Qualia Senolytic—quercetin phytosome.

In the study, which aimed to test the enhanced solubility of the formulation in vitro as well as with (twelve) human participants, the authors reported that “No significant differences were observed between the three treatments in vital signs, physical examination results, or ECG results, so the study demonstrated that the new formulation is safe and well tolerated….”


Piperlongumine was shown in this Ditmanson Medical Foundation (of Taiwan) study to have no pathological effect on the liver or kidneys of any of the mice in the sample, including a complete lack of immune cell infiltration in any of the tissues tested. 


Senactiv achieved self-affirmed US GRAS (generally recognized as safe) status, a hard-to-attain safety designation upheld by the FDA, in 2015 after a 28-day oral dose toxicology report (in rats) demonstrated the ingredient’s safety. 


Finally, the curcumin in turmeric has been implicated by more than one more recent report as a potential inducer of liver toxicity, despite being used medicinally for more than three millennia (yes, millennia), but the majority of the scientific community is not buying it.

For example, this systematic review from the University of California at San Francisco covering six human trials involving curcumin use reported zero adverse effects or measured toxicity. 

Though we have some human trial safety data, we would like to see a larger library covering all of these ingredients, especially with the added benefit of clearer dosage guidelines. 

The record as it stands now is solid, but still incomplete, which brings us to a grade of A for safety. 

Brand Experience


Grade: A-

Except for a few small hitches, the online shopping experience, supporting information, customer service, and money-back guarantee provided by Neurohacker are consistent with top-tier supplement brands.

Even when reviewing a single product, you can’t ignore the influence that the overall brand experience—including the shopping experience, consumer education, customer service, and more—has on your perception of the product, which is why we include them in product reviews.

As for ecommerce experience, Neurohacker makes it easy to browse their catalog and purchase products on their site, though we would like to see a “shop all” function and a more visible description of how long the product is intended to last under recommended use conditions (“x-day supply,” requires scrolling pretty far down on product pages to see).

Nobody we’ve reviewed comes even remotely close on the consumer education front, as Neurohacker site visitors have access to volumes upon volumes of actionable, relevant, and clearly articulated pieces of content explaining the rationale behind each product, the science-supported claims behind each ingredient, and more.

Neurohacker offers call, text, and email support, all of which we tested.

The text and email channels provided very prompt and accommodating responses to our questions, but after leaving a voicemail on the phone service, we never received a response.

Finally, Neurohacker maintains a very generous 100-day money back guarantee, allowing customers to receive their money back if they aren’t 100% satisfied within this time window, without even requiring the product to be returned.

Their shipping policy is located in their FAQs and, at the time of publication, standard shipping is $7.98 while priority shipping is $12.98.

Minus a few small bumps in the road, Neurohacker backs up their products like Qualia Senolytic with strong customer service, consumer education, and more, which earns them a grade of A- for brand value. 

Value for the Price


Grade: A-

Rather than haggle over apples-to-oranges comparisons against other supplements with not-so-similar formulations, we assessed the value of Qualia Senolytic based on how well Neurohacker demonstrated the potential benefits of this product, coming to a grade of A-.

Non-subscription purchasers of Qualia Senolytic will pay $79 for a month’s supply, and subscribers can hack 50% off their first purchase ($39.50) with the added benefit of a regular $10 discount on subsequent orders ($69).

Use code NUTRITIONINSIDER for 15% off.

Each month requires only two six-capsule servings, as Qualia Senolytic is meant to be used as part of a two-day rejuvenation regiment on a monthly basis.

Neurohacker spaces out the recommended doses in this way because most of the research does the same, both citing a latency effect of several weeks as it applies to the return of senescent cells.

As for the value assessment, the very far-reaching pathological potential of cellular senescence made it more difficult than usual for us to assign a score here, as Qualia Senolytic may be a complete game changer for some and perhaps less effective for others depending on age, medical history, and so forth. 

If this were a more narrowly focused supplement, e.g., a sleep supplement, we could more easily use apples-to-apples comparisons with other products to balance effectiveness with value, but we’re left in this broader and more subjective case to lean on what we know about the brand, the ingredients, and the research supporting them.

Long answer short, the perceived value of this product can vary greatly from person to person, but in acknowledgment of the sound, research-supported formulation (and a credit boost for the subscription program), we’re giving Qualia Senolytic an A- for value.

Our Experience

Given the six-capsule serving size, our review team appreciated the smaller (than Qualia Mind) capsule size in this case, which made Qualia Senolytic much easier to take.

The blister packaging was very easy to work with; the pills popped out without a hassle. 

As expected, the capsules were tasteless, including a lack of aftertaste other than a very subtle note of that hard-to-describe, “papery” capsule taste.

Though the potency and immediacy of noticed effects are sure to vary based on the person, this generally isn’t the kind of product that you feel working within hours.

However, after a few days, we did notice some improvements in cognition and energy; it felt easier to stay focused for longer and with less burnout after more intensive tasks, almost like an energy drink but without the peaks and crashes.

Our Verdict

All of the active ingredients in Qualia Senolytic have been thoroughly researched by Neurohacker themselves and many other parties in this burgeoning field of senolytics.

We’re convinced by the current knowledge base that the ingredients are equally as safe as they are likely to impart their advertised benefits, which are very broad in this case because of the sweeping influence of cellular senescence on the body.

The product is reasonably priced for the formulation and the healing potential that comes with it, and Neurohacker takes a very pro-consumer approach in supporting each customer’s buying decision with volumes of beginner-friendly information, solid customer service, and an industry-leading satisfaction guarantee.

Finally, though this once-a-month product requires longer trial periods to more accurately gauge results, our personal experiences with Qualia Senolytic were consistent with Neurohacker’s claims.

For these reasons, we award Qualia Senolytic an overall grade of A and will continue to recommend it to anyone of cellular retirement age.

Qualia Senolytic
  • Description

    Qualia Senolytic uses a balanced synergy of plant-derived compounds like fisetin, curcumin, and more to selectively kill aging, senescent cells in our tissues.

  • Ingredients

    Fisetin, Quercefit ® Quercetin Phytosome, Longvida Optimized Curcumin ® Extract, Olive Leaf Extract, Soybean Seed Extract, Luteolin, Milk Thistle Seed Extract, Piperlongumine, Senactive ®

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