Onnit Total Human Review


Our Rating: A-

We determined this rating by evaluating the following factors:

  • Ingredient Quality
    Ingredient QualityA-
    The ingredients and formulations found in the ten supplements of Onnit Total Human were excellent, but we hoped for more certifications backing the product.
  • Supporting Research
    Supporting ResearchA-
    Most of the ingredients have a strong backing with clinical research, but some are too new to the scene to have solid evidence supporting their effectiveness yet.
  • Reported Side Effects
    Reported Side EffectsA-
    The potential side effects are minor (like digestive upset), but many of the compounds do not have long-term safety data yet.
  • Brand Experience
    Brand ExperienceA
    Onnit’s customer service was responsive and helpful, and the return policy is generous, but the free shipping threshold is steep.
  • Value
    Although it’ll cost you almost $140 for a month’s supply, using this as an all-in-one supplement stack is reasonably priced compared to buying them all separately.
Our Editorial Policy

If you’re tired of having dozens of supplement bottles lining your shelves, making it nearly impossible to travel with your full supplement stack, Onnit Total Human is for you.

Made up of a handy “day pack” and “night pack” containing a comprehensive set of vitamins and minerals, omega-3s, functional mushrooms, adaptogens, nootropics, and more, Onnit Total Human is an all-in-one product that may benefit cognitive, cardiovascular, immune, bone, and aerobic health. 

With well-thought-out formulations, good value, and above-average customer service, we awarded Onnit Total Human an overall A- rating—keep reading to see how this product measured up.

Onnit Total Human
Onnit Total Human
  • Description:

    For people who want to ditch their multivitamins and other dietary supplements, Onnit Total Human’s day and night packs are a comprehensive, 16-pills-per-day solution that covers all of your nutritional bases—and then some.

  • Ingredients:

    Contains the following Onnit supplements: StronBONE, Alpha Brain, Krill Oil, Total Human B Complex, Shroom Tech Sport, Spirulina & Chlorella, Shroom Tech Immune, New Mood, ViruTech, and Key Minerals.

Pros and Cons

  • Pros
  • Day and night packs are highly convenient
  • Reasonably priced relative to quality
  • Great supplement formulations
  • Responsive customer service
  • Cons
  • 16 pills/capsules per day
  • May cause digestive issues as a side effect
  • Some ingredients do not have long-term safety data or solid research

Our Onnit Total Human Review

We awarded Onnit Total Human an overall A- grade, with higher points for ingredient formulation, excellent customer service, and a reasonable price for the quantity of supplements provided.

Onnit Total Human Scores: 

  • Ingredient Quality: A-
  • Supporting Research: A- 
  • Reported Side Effects: A-
  • Brand Experience: A
  • Value: A
Onnit Total Human Day and Night Support

Ingredient Quality


Grade: A- 

The ingredients and formulations found in the ten supplements of Onnit Total Human were excellent, but we hoped for more certifications backing the product.

In this category, we assess the overall quality of ingredients, which also encompasses sourcing, testing, and manufacturing processes. 

We awarded Onnit higher points for their supplement formulations, which are low in “filler” ingredients and use clinically backed forms and doses. 

They prioritize sourcing ingredients from various partner farms that practice sustainable, humane methods, and the products are manufactured at Onnit’s headquarters in Austin, Texas.

Their supplements are tested by third-party labs for contaminants and banned substances, and many boast the Rainforest Alliance seal—meaning they support the “three pillars of sustainability: social, economic, and environmental.” 

However, we would like to see more certifications on this product.

Supporting Research


Grade: A-

Most of the ingredients have a strong backing with clinical research, but some are too new to the scene to have solid evidence supporting their effectiveness yet.

As Onnit Total Human is comprised of ten supplements with dozens of compounds, we’re not going to bore you by going through the research of each and every one—but we will call out one or two of the most critical from each supplement.

In the Onnit Total Human Day Pack, you’ll find:

  • StronBONE
  • Alpha Brain
  • Krill Oil
  • Total Human B Complex
  • Shroom Tech Sport
  • Spirulina & Chlorella
  • Shroom Tech Immune

The Onnit Total Human Night Packs contain:

  • New Mood
  • ViruTech
  • Key Minerals
  • Krill Oil
  • Shroom Tech Immune
  • Spirulina & Chlorella

Let’s take a closer look at some of the compounds found in these supplements and the research behind them.

Day Pack Supplement Facts
Day Pack Supplement Facts
Night Pack Supplement Facts
Night Pack Supplement Facts


StronBONE is a mineral-heavy supplement designed to fortify bone strength and support bone mineral density. 

The primary ingredients are vitamin K2, boron, strontium, copper, vitamin E, and manganese, which help the body send calcium to the bones, activate proteins that mineralize bones, and act as cofactors for many of the enzymes needed for bone formation. 

These minerals have a solid research base backing up their use in bone health.
For example, this 2016 review discusses the benefits of strontium for bone mineral density and preventing osteoporosis, while a paper from 2020 concludes that vitamin K2 is efficacious and safe in treating bone loss.

Alpha Brain

Alpha Brain is Onnit’s signature nootropic supplement, designed to improve focus and cognitive function. 

The key ingredients include vitamin B6, L-tyrosine, cat’s claw, L-theanine, alpha-GPC, Bacopa, pterostilbene, and Huperzia serrata.

Not all of these compounds have a solid research base on how they impact cognitive function, but several do. 

For example, L-theanine is thought to increase “flow” state and enhance attention, L-tyrosine has been found to improve cognitive performance in young adults, and Bacopa extract significantly increased visual information processing, learning, and memory recall in a study of healthy adults.

For more details about these ingredients and Alpha Brain as a whole, read our comprehensive review here.

Krill Oil

Krill oil is a rich source of omega-3 fatty acids, which are vital for cardiovascular and cognitive health, and astaxanthin, a potent antioxidant.

Compared to fish oil, krill oil is a more sustainable and less toxic alternative than fish oil, as it has a lower potential for mercury, PCB, and pesticide accumulation. 

Onnit’s Krill Oil supplement contains krill oil itself as well as astaxanthin, omega-3 fats (DHA and EPA), and phospholipids.

Total Human B Complex

It looks like Onnit does not sell their B Complex separately anymore, but this nutrient-rich blend found in Total Human contains vitamins B1 (thiamine), B2 (riboflavin), B5 (pantothenic acid), B9 (folate), and biotin. 

It also has benfotiamine, a fat-soluble derivative of thiamine that allows it to penetrate nerve cells. 
B vitamins are critical for hundreds of processes in the human body, including energy metabolism, neurotransmitter production, DNA synthesis, and many cellular metabolic pathways.

Shroom Tech Sport

Shroom Tech Sport is Onnit’s top athletic performance supplement, loaded with cordyceps mushrooms, vitamin B12, chromium, green tea extract, and adaptogens like ashwagandha, astragalus, and Rhodiola. 

It’s also the only Onnit supplement with a clinical trial to back up its benefits.

In this study of college-aged men, supplementing with Shroom Tech Sport for 12 weeks led to significant increases in exercise performance, including:

  • Increased bench press reps by 12%
  • Increased bench press and back squat reps by 7%
  • Increased cardio performance by 8.8%

Spirulina & Chlorella

Derived from blue-green algae, Spirulina & Chlorella is a green superfood supplement that may help with detoxification, heart health, and immune health.

Spirulina and chlorella are loaded with micronutrients and plant-based protein, and research shows they act as antioxidants in the body. 

Chlorella may especially be beneficial for cardiovascular health, as this review concluded that supplementing with it improved total and LDL cholesterol, blood pressure, and fasting blood glucose levels.

Shroom Tech Immune

Shroom Tech Immune is unsurprisingly loaded with functional mushrooms, including organic chaga, Agaricus blazei, cordyceps, Coriolus, reishi, maitake, and shitake.

Only some of these mushrooms have a solid evidence base, but chaga is becoming more well-known for its role in supporting immunity, and cordyceps has been found to modulate the activity of cytokines (a class of proteins that regulate inflammation and other functions) and immune cells. 

Shroom Tech Immune also has a blend of turmeric, ginger, oregano, lemon peel, and black pepper, which have anti-inflammatory, antioxidant, and immunomodulating benefits.

New Mood

Another well-known Onnit product is New Mood, containing vitamin D, vitamin B6, niacin, magnesium, valerian root, chamomile, lemon balm, jujube, L-tryptophan, and 5-HTP. 

These ingredients are thought to promote relaxation, sleep, and serotonin production, potentially leading to better moods and reduced stress. 

L-tryptophan and 5-HTP are both precursors to serotonin, which explains their role in promoting better moods. Researchers in this systematic review concluded that L-tryptophan supplementation significantly decreased anxiety and increased positive mood.

The herbs in New Mood are thought to support relaxation and sleep—like lemon balm (also known as Melissa officinalis), which was found to reduce scores of depression, anxiety, stress, and total sleep disturbances in an 8-week trial.

However, other compounds don’t have as much of a solid research backing. While chamomile is definitely a soothing tea, research is inconclusive on its benefits—some studies show that chamomile improves sleep quality, while others show no effect on insomnia or anxiety.


Onnit ViruTech is loaded with immune-supporting nutrients we all know and love—like vitamin C, zinc, and selenium—and some lesser-known compounds, like lysine, quercetin, and alpha-lipoic acid.

Many of these ingredients are also rich in antioxidants, which can fight oxidative stress in the body. 

Research shows that vitamin C and zinc are vital for healthy immune function, and L-lysine (an amino acid) is known for fighting viral infections. 

We also have evidence of the benefits of quercetin, an antioxidant compound found in plants like apples and onions that reduces inflammation and has antiviral properties.

Key Minerals

Lastly, Onnit Total Human contains Key Minerals—a mix of five, well, key minerals (calcium, iodine, magnesium, molybdenum, and boron). 

This formulation also provides lesser-known minerals like molybdenum, which is a cofactor for enzymes needed for amino acid metabolism and detoxification, and boron, a trace mineral shown to support bone health and cognitive function.

Reported Side Effects


Grade: A-

The potential side effects are minor (like digestive upset), but many of the compounds do not have long-term safety data yet.

As Onnit Total Human contains ten different supplements with dozens of compounds, the potential for side effects is relatively high. 

However, the known adverse effects appear to be minor, including digestive problems and nausea. 

Lemon balm (found in New Mood) may cause the most significant side effects, with reports of nausea, dizziness, GI issues, headache, and wheezing—but that’s typically seen at doses of 2 grams or more. 

It’s also challenging to know all of the contraindications with each supplement, or the factors that make people ineligible for any given supplement based on the interaction of said supplement with a pre-existing condition or other issues that vary from person to person. 

If you didn’t visit each individual supplement page, you wouldn’t know some of the precautions—for example, StronBONE states, “Do not take this product if you have advanced kidney problems or are taking Quinolone or Tetracycline antibiotics. Consult a medical doctor if you are at high risk of blood clotting or are taking blood thinning medication.”

Also, 5-HTP and L-tryptophan (found in New Mood) should not be taken in combination with antidepressants known as selective serotonin reuptake inhibitors (SSRIs). 

Overall, the side effects appear to be minor—but we’d recommend checking out each product page if you’re on medications or have a chronic disease to be sure the supplement doesn’t interact with your specific health conditions (or speak with your doctor).

Brand Experience


Grade: A

Onnit’s customer service was responsive and helpful, and the return policy is generous, but the free shipping threshold is steep.

In this section, we assess customer service, website experience, and availability of consumer education.

Onnit scored high for their customer service, as we were connected with an actual human—who responded helpfully and rapidly—on their chat system within a minute. 

They also offer a 90-day money-back guarantee on their products, making it a risk-free experience for a first-time buyer.

However, you only get a full refund if you have used less than half of the product—otherwise, you just get store credit (still not a bad deal). 

One area we docked some points in is the free shipping threshold—at $150, that’s pretty steep, and even a $140 purchase of Total Human won’t get you there. 

We also appreciated the ingredient breakdown and supporting clinical research for each supplement, although you can find much more on each individual product page (rather than the Total Human page).



Grade: A

Although it’ll cost you almost $140 for a month’s supply, using this as an all-in-one supplement stack is reasonably priced compared to buying them all separately.

At $137.95 for a one-time purchase with 30 day-and-night packs, Onnit Total Human is definitely not inexpensive (but a subscription will drop it down to $117, by the way). 

But the price might be worth it if you are already taking many of these supplements and want to simplify your regimen. 

Each two-pack worth of supplements comes out to $4.60 per day, and you would save 40% compared to if you were already buying these supplements separately. 

However, if you eat a well-rounded diet and don’t think you’re short on vitamins and minerals (which many of these supplements are based around, like the B Complex, StronBONE, and Key Minerals), you may be better off solely purchasing the ones you want separately. 

That said, many people are not eating adequate amounts of micronutrients (despite thinking that they are) for reasons including declining soil quality that impacts mineral content and plant foods containing significantly fewer nutrients now than they did in the past.

Combining these factors, we landed on a solid A for value here.

Our Experience with Onnit Total Human Day and Night Packs

First things first—if you do not like taking pills, Onnit Total Human is likely not for you. 

With 16 pills to pop per day, Total Human is not for the faint of heart. However, we will say that you won’t find any horse pills in the pack, and some are even downright tiny. 

Upon taking a day pack in the morning, we experienced a slight boost in mental energy and focus (thanks, Alpha Brain), with no unwanted symptoms or off-putting aftertastes.

Onnit Total Human Day Pack

After popping open a night pack, we felt a bit more relaxed and fell asleep relatively quickly. 

However, the effects were not overstated—we did not get overly sleepy or drowsy.

Onnit Total Human Night Support

Overall, our experience with Total Human was a good one—the only downside was taking eight pills each time, but some effects were noticed in a positive way.

Final Thoughts

We would recommend Onnit Total Human to anyone looking to cover any nutritional gaps in their diet and support areas of health related to immune function, bone strength, exercise performance, heart health, mood, and focus—what more could you ask for?

Although Total Human is expensive, it is actually reasonably priced relative to the sheer quantity of supplements that you get—especially if you are already forking out your cash for a well-crafted supplement stack. 

Overall, Total Human is a comprehensive nutrient, nootropic, and adaptogen formulation with some solid research behind the ten supplements in this day and night regimen, and the A- grade we gave the product reflects that.

FAQs About Onnit Total Human

What Does Onnit Total Human Do?

Onnit Total Human is a convenient option that could replace all your multivitamins and supplements. It contains a day and night pack filled with micronutrients, adaptogens, functional mushrooms, nootropics, and more. Onnit did all the hard work for you, figuring out the correct doses, combinations, and time to take them.

Is Onnit Total Human Worth It?

On strictly a cost-per-supplement basis, Onnit Total Human is worth it. If you were to buy every supplement found in Onnit Total Human separately, you’d spend 40% more than purchasing the comprehensive day and night packs. If you struggle to meet your nutritional needs through diet—or if you already buy several of the more pricey Onnit supplements (like Alpha Brain and Shroom Tech Sport), you’d likely be better off purchasing Onnit Total Human.

What Are the Benefits of Taking Onnit Total Human?

The potential benefits of Onnit Total Human include filling any nutritional gaps in your diet, supporting brain and cognitive function, and improving focus, immune function, and athletic performance.

Is There Alpha Brain in Total Human?

Yes, you’ll find Onnit Alpha Brain in the day pack of Total Human. Onnit Alpha Brain contains nootropic and brain-boosting ingredients like vitamin B6, L-tyrosine, cat’s claw, alpha-GPC, Bacopa, pterostilbene, and Huperzia serrata. Read more about Alpha Brain in our comprehensive review here.

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